Phase interrogation surface plasmon resonance hyperspectral imaging sensor for multi-channel high-throughput detection

Phase interrogation surface plasmon resonance (SPR) imaging is, in principle, suitable multiple samples and high-throughput detection, but the refractive index difference of various can be largely varied, while dynamic range phase SPR is narrow. So it difficult to perform multi-sample detection mode. In this paper, we successfully designed a multi-channel sensing scheme based on common optical interference path between p- s-polarized light without using any mechanical moving components. The fixed introduced by birefringence crystal produce sinusoidal spectral fringes. We adopted time-division-multiplexing peak-finding algorithm track wavelength so that cover every channel. values which carry high sensitivity signal corresponding are calculated iterative parameter scanning cross-correlation algorithm.